4 stars (4)
- Broadway Plaza, Trademark Collection By Wyndham Rochester
- Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area Rochester
- Hilton Rochester Mayo Clinic Area
- The Berkman Hotel Rochester
3 stars (31)
- Americinn By Wyndham Rochester Near Mayo Clinic
- Aspen Suites - Rochester
- Best Western Rochester Hotel Mayo Clinic Area/ St. Mary'S
- Brentwood Inn And Suites Rochester
- Comfort Inn & Suites West - Medical Center Rochester
- Country Inn & Suites By Radisson - Rochester
- Courtyard Rochester Mayo Clinic Area/Saint Marys
- Days Inn & Suites By Wyndham Rochester South
- Doubletree By Hilton Rochester - Mayo Clinic Area
- Fairfield Inn & Suites By Marriott Rochester Mayo Clinic Area/Saint Marys
- Hampton Inn & Suites Rochester-North
- Hampton Inn Rochester
- Hilton Garden Inn Rochester Downtown
- Holiday Inn Express And Suites Rochester West-Medical Center, An Ihg Hotel
- Home2 Suites By Hilton Rochester Mayo Clinic Area
- Homewood Suites By Hilton Rochester Mayo Clinic-St. Marys Campus
- Hotel Indigo Rochester - Mayo Clinic Area
- Hyatt House Rochester Mayo Clinic Area
- Kahler Grand Hotel Rochester
- Kahler Inn And Suites Rochester
- La Quinta By Wyndham Rochester Mayo Clinic Area South
- Med City Hotel & Suites Rochester
- Microtel Inn & Suites By Wyndham Rochester South Mayo Clinic
- Residence Inn Rochester Mayo Clinic Area
- Rochester Marriott Mayo Clinic Area
- Springhill Suites Rochester Mayo Clinic Area / Saint Marys
- Staybridge Suites Rochester - Mayo Clinic Area, An Ihg Hotel
- Staybridge Suites Rochester, An Ihg Hotel
- Super 8 By Wyndham Rochester Mayo Clinic Area
- Towneplace Suites By Marriott Rochester Mayo Clinic Area
- Towneplace Suites Rochester
2 stars (21)
- 2Nd Street Inn & Suites Rochester
- 5Th Avenue Inn & Suites Rochester
- Americinn By Wyndham Rochester
- Aspen Select Hotel Rochester
- Baymont By Wyndham Rochester Mayo Clinic Area
- Brentwood On 2Nd Hotel Rochester
- Country Inn & Suites By Radisson, Rochester South, Mn
- Days Inn By Wyndham Rochester Downtown
- Extended Stay America Suites - Rochester - North
- Mainstay Suites Rochester South Mayo Clinic
- Med City Inn & Suites Rochester Mayo Clinic Area
- Microtel Inn & Suites By Wyndham Rochester North Mayo Clinic
- Motel 6-Rochester, Mn
- Quality Inn & Suites Mayo Clinic Area Rochester
- Quality Inn Near Medical Center Rochester
- Ray Mar Motel Rochester
- Red Carpet Inn Rochester
- Riverview Suites Rochester
- Rochester Inn
- Sleep Inn & Suites West-Near Medical Center Rochester
- Travelers Hotel Rochester